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The mechanical-inflammatory link is also supported by research on TBI, which was shown to be associated with CNS inflammation (and can lead to a clinical picture overlapping with ME/CFS) (Nordin et al., 2016)

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A meta-analysis of randomized trials has demonstrated that metformin lowers the incidence of miscarriage (RR = 0.86, 95% CI: 0.67–1.12), preeclampsia (RR = 0.45, 95% CI: 0.24–0.83), and preterm delivery (RR = 0.37, 95% CI: 0.23–0.61) in PCOS patients (Moghetti et al., 2000